atrial fibrillation (AF), valvular heart disease, congenital heart disease, and other indications. IntroductionĪnticoagulation is utilised in the management of venous thromboembolism and to prevent thrombotic complications in patients with cardiac comorbidities, e.g. We discuss their indications for use, dosing, and potential side effects. This review provides guidance relating to specific direct oral anticoagulant (DOAC) reversal agents, the antidotes. Bleeding, depending on the severity, is managed in various ways, and for severe or life-threatening bleeding, specific antidotes are indicated and recommended. Bleeding is the commonest and most concerning adverse event associated with anticoagulants.
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